Molecular cloning and characterization of taurocyamine kinase from Clonorchis sinensis: a candidate chemotherapeutic target.

BACKGROUND: Adult Clonorchis sinensis lives in the bile duct and causes endemic clonorchiasis in East Asian countries.Phosphagen kinases (PK) constitute a highly conserved family of enzymes, which play a role in ATP buffering in cells, and are potential targets for chemotherapeutic agents, since variants of PK are found only in invertebrate animals

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Graph contrastive learning with node-level accurate difference

Graph contrastive learning (GCL) has attracted extensive research interest Tennis Balls due to its powerful ability to capture latent structural and semantic information of graphs in a self-supervised manner.Existing GCL methods commonly adopt predefined graph augmentations to generate two contrastive views.Subsequently, they design a contrastive p

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